Thymosin Beta 4 (TB500)
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Also known as Thymosin Beta 4 TB500 5mg, Thymosin Beta 4, TB500, TB-500, TB 500, Thymosin Beta-4, Thymosin B4
Thymosin Beta 4 TB500 is a research peptide. ThymosinB4 is a 43-amino acid protein that is in all animal cells including humans. TB500 is a synthetic peptide of this protein. TB 500 upregulates the proteins that build cells. It increases the number of cell building proteins such as Myosin and Actin. These components control movement in the form of muscle contractions. Actin builds new pathways for blood vessels to help heal the wounds and muscle tares.
Molecular formula: C212H350N56O78S
Thymosing Beta 4 TB500 Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
CAS number: 77591-33-4
Molar Mass: 4963.4408 g/mol
PubChem CID: 16132341
TB-500 studies have concentrated on the acceleration of skin healing, especially in burns, ulcers, and wounds. The studies show the increase in blood vessel formation, or angiogenesis, along with anti-inflamatory activity and an increase in platelet aggregation at the specific burn or wound sites.
Studies with mice showed that subjects given Thymosin Beta 4 TB 500 showed improved strength in healed bone fractures compared to the untreated subjects.
A study with rats that had minor spinal cord injuries due to compression showed that those treated with Thymosin Beta 4 had improved locomotor functions and an 57.8% increase in Myelin proteins. The study proved that TB-500 should be considered for clinical trials to potentially treat spinal cord injuries.
Thymosin Beta-4 TB500 peptide also showed an increase in blood flow, the production of new brain cells and even new connections between the brain cells in rats during studies.
In 2015, studies showed improvement of the tissue regeneration in the heart following a heart attack and most notable the healing of brain tissue following trauma, neurological diseases and stroke.
Further studies have shown clinical improvements of liver and kidney diseases, bone and ligament injuries and spinal cord repair.
TB-500 is a research peptide and is sold for research purposes only. It is not for human consumption.