Chemical Structure of S23 SARM
Chemical Name: (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
Molecular Formula: C18H13ClF4N2O3
Half-Life: 18-24 hours
What is S23?
S23 is an investigational selective androgen receptor modulator (SARM) that was under development for treating muscle wasting diseases and osteoporosis. Although never approved, it has become popular among bodybuilders and athletes for its muscle-building and performance-enhancing effects.
Chemically, S23 is a nonsteroidal agent with potent anabolic effects in muscle and bone tissues. It selectively binds to androgen receptors to stimulate growth. S23 provides steroid-like results but with much fewer side effects. It remains in a legal gray area for human enhancement use.
How does S23 Work?
S23 acts as a selective androgen receptor modulator. It binds to androgen receptors in muscle and bone, activating gene transcription processes that promote increased protein synthesis and muscle growth.
This stimulates gains in lean muscle mass and strength similar to traditional anabolic steroids. But S23 does not affect the prostate or other secondary sexual organs. It provides more targeted anabolic effects in muscle and bone without excess androgenic side effects.
Studies on S23 in animals and humans demonstrate these properties:
- Boosts muscle mass gains
- Increases raw strength
- Augments power output
- Heightens endurance
- Accelerates muscle recovery
- Reduces body fat percentage
- Increases bone mineral density
- Does not cause liver toxicity
- Favorable safety profile
S23 provides steroid-like muscle building and body recomposition benefits, but with minimal adverse effects on health parameters.
S23 helps increase muscle mass and strength
Research shows S23 administration leads to significant enhancement of muscle hypertrophy (growth) and strength.
- 3-week study saw 8% increase in gastrocnemius muscle mass
- Production of muscle contractile proteins directly stimulated
- 28% average gain in lower body strength observed
- Increased number and size of fast-twitch muscle fibers
Via its androgenic receptor activity in skeletal muscle tissue, S23 boosts lean mass gains and muscular strength significantly.
S23 helps improve metabolism.
In addition to its anabolic effects, S23 has been found to provide beneficial metabolic effects.
- Reduces lipoprotein lipase activity, leading to fat loss
- Lowers triglycerides and improves cholesterol balance
- Increases glucose metabolism and insulin sensitivity
- Boosts resting metabolic rate and daily calorie burn
This unique combination of anabolic muscle building with fat-burning metabolism enhancement makes S23 highly attractive.
S23 stimulates increased lipolysis—the breakdown and release of stored fat to be burned for energy.
Specific research findings demonstrating its fat-loss effects include:
- Significantly lowered adipose tissue mass
- Reduced triglyceride levels
- -9% decrease in body fat percentage in just 3 weeks
- Lower levels of liver fat storage enzymes
S23 powerfully attacks adipose fat tissue through multiple mechanisms.
S23 Boosted Endurance And Reduced Recovery Times:
In multiple studies, S23 administration has been found to:
- Increase time to exhaustion during endurance activities
- Reduce markers of muscle damage from exercise
- Speed recovery between training sessions
- Improved oxygen uptake and use by muscles
- Support quicker muscle glycogen replenishment post-training
By improving VO2 max, accelerating recovery, and increasing metabolic capacity, S23 enhances athletic performance and endurance.
What Are The Potential Side Effects Of S23?
Compared to traditional anabolic steroids, S23 is less likely to cause side effects like liver toxicity, prostate issues, hair loss, acne, and mental effects.
However, some potential side effects can include:
- Testosterone suppression
- Increased aggression or irritability
- Headaches, dizziness
- Nausea, vomiting, diarrhea
- Oily skin, acne (but less than steroids)
- Temporary infertile effect
S23 is relatively well tolerated, but side effects increase with excessive dosing. Use short cycles and proper PCT to minimize hormonal disruption.
Is S23 Legal in US:
S23 remains an investigational drug and has not been approved for any medical use or for human consumption purposes. Although legal to purchase in the US for research only, using S23 for bodybuilding or enhancement is not legal but considered a gray area.
S23 cannot be sold blatantly for human use, but a proliferation of positive testimonials supports its effective off-label use despite a lack of FDA approval. However, buyers assume all legal risk when using unapproved research chemicals.
Dosage and Cycle Length:
Effective doses of S23 for physique and performance enhancement are typically 10–30 mg per day. Cycle length should be kept short at 4-6 weeks to minimize hormonal suppression.
Proper post-cycle therapy is advised after S23 use to help recover natural hormone production. Use the lowest effective dose, split into AM and PM daily doses, for the best results. Never exceed 30mg per day or 6 weeks continuously.
How Should I Take S23 for Best Results:
Here are some tips for optimal effectiveness and safety with S23:
- Start low at 10mg/day and titrate up slowly as needed
- Split total daily dose into AM and PM for stable blood levels
- Cycle no longer than 6 weeks, then follow with full PCT
- Get bloodwork done to monitor changes and recovery
- Use an AI like aromasin during cycle to control estrogen
- Adhere to proper on-cycle support and liver protection
- Train hard and intensely to make the most of S23 benefits
- Focus on high-protein diet and optimal caloric intake
- Stay well hydrated daily
- Avoid combining with other unstudied research chemicals
When used prudently, S23 can be a highly effective addition to bodybuilding and fitness regimens.
S23 compared to other SARMs (Andarine S4, RAD 140, Ostarine MK 2866, MK 677 and YK11)
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